The overuse or incompetent use of antibiotics leads to a very dangerous phenomenon – drug resistance. Judicious use and, in some cases, abandoning the use of antibiotics altogether is the only way to stop the antibiotic resistance epidemic. Otherwise, some infectious diseases will soon become fatal again. The One Health – One Health drip addresses all sectors where antibiotics are used, and it is not just medicine. Veterinary medicine, horticulture, agriculture and the food industry must also find other solutions. In the SafeFood Crtl and PrevEco projects, we are developing alternative methods of fighting bacteria based on enzybiotics – bactericidal enzymes to meet the needs. In this way, antibiotic-resistant strains of Staphylococcus aureus or Escherichia coli can still be combated.